L-alpha-amino acid transmembrane transport

Across TCGA cell cohorts, RNA activity of the L-alpha-amino acid transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A1, LAMP2, and CENPV, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-alpha-amino acid transmembrane transport activity versus SLC2A1 in LARGE_INTESTINE (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC2A1 →	+2.406	+0.242	<.001	<.001	3	6
LARGE_INTESTINE	LAMP2 →	+0.708	+0.173	<.001	<.001	3	6
URINARY_TRACT	CENPV →	-2.912	-0.330	.001	.007	2	6
STOMACH	A4GALT →	+2.661	+0.410	.002	<.001	2	6
STOMACH	ARRB2 →	-1.311	-0.325	<.001	.002	3	5
STOMACH	SLC43A1 →	-3.880	-0.401	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902475 vs SLC2A1 — LARGE_INTESTINE

Explore this scatter interactively →