Positive regulation of protein localization to synapse

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein localization to synapse pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAB11FIP5, ISLR, and MAP1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to synapse activity versus RAB11FIP5 in PDAC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RAB11FIP5 →	+0.289	+0.092	<.001	<.001	3	6
BRCA	ISLR →	+0.620	+0.086	<.001	<.001	3	6
LSCC	MAP1A →	+0.493	+0.089	.001	.001	3	5
GBM	MAP1A_S1218 →	+0.523	+0.075	.002	.001	3	5
LSCC	MAP1A_S667 →	+0.656	+0.095	.002	<.001	3	5
OV	HADH →	-0.541	-0.101	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902474 vs RAB11FIP5 — PDAC

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