Positive regulation of protein localization to synapse

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to synapse pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OR52W1, MAP2K4, and C1orf159, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OR52W1 grouped by Positive regulation of protein localization to synapse-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OR52W1 →	+0.024	+1.005	.008	.006	3	4
LUNG_SCLC	MAP2K4 →	-0.714	-1.134	<.001	<.001	3	4
BONE	C1orf159 →	-0.966	-1.322	<.001	.002	3	4
SKIN	TSPAN13 →	-1.861	-0.986	.002	.008	3	3
SKIN	DPP9 →	+0.380	+0.747	.005	.009	3	3
STOMACH	AAK1 →	-1.035	-1.269	.007	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OR52W1 by Positive regulation of protein localization to synapse activity — KIDNEY

Explore this box plot interactively →