Positive regulation of protein localization to synapse

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to synapse pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAFB2, NDST4, and IRF3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SAFB2 grouped by Positive regulation of protein localization to synapse-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SAFB2 →	-0.226	-0.314	.007	.009	2	6
LIVER	NDST4 →	-0.181	-0.161	.001	.003	3	4
SKIN	IRF3 →	-0.132	-0.148	.001	.001	3	4
STOMACH	VAV2 →	-0.147	-0.290	.003	.003	3	4
CNS	LMNA →	+0.304	+0.163	.005	.001	3	4
LARGE_INTESTINE	GSK3A →	-0.125	-0.156	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SAFB2 by Positive regulation of protein localization to synapse activity — BONE

Explore this box plot interactively →