Regulation of protein localization to synapse

Across TCGA patient cohorts, RNA activity of the Regulation of protein localization to synapse pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are YEATS2_S447, LIG1_S76, and RRP36_S73, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to synapse activity versus YEATS2_S447 in OV (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	YEATS2_S447 →	-0.929	-0.873	<.001	<.001	3	4
LUAD	LIG1_S76 →	-0.808	-0.664	<.001	.002	3	4
LUAD	RRP36_S73 →	-0.715	-0.611	.002	.005	1	5
LSCC	SEPTIN9_S41 →	+0.852	+0.781	.001	.004	3	3
LSCC	SEPTIN9_S59 →	+0.852	+0.781	.001	.004	3	3
COAD	SGCE →	+0.506	+0.854	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902473 vs YEATS2_S447 — OV

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