Regulation of protein localization to synapse

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to synapse pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD44, BCOR, and PDHA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANKRD44 grouped by Regulation of protein localization to synapse-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ANKRD44 →	+0.207	+1.031	.008	.002	3	4
CNS	BCOR →	-0.150	-1.383	.006	<.001	3	3
BREAST	PDHA2 →	-0.107	-0.905	.009	.003	3	3
BREAST	PRSS27 →	-0.182	-0.978	.009	.007	2	4
BREAST	SLITRK4 →	-0.177	-0.981	<.001	.001	3	3
LUNG_SCLC	ANKRD36B →	-0.312	-1.915	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANKRD44 by Regulation of protein localization to synapse activity — LARGE_INTESTINE

Explore this box plot interactively →