Protein localization to cell leading edge

Across TCGA patient cohorts, RNA activity of the Protein localization to cell leading edge pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STK4_S414, ADGRL4, and DOCK2_S1784, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to cell leading edge activity versus STK4_S414 in PDAC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	STK4_S414 →	+0.813	+0.088	<.001	<.001	3	7
UCEC	ADGRL4 →	+0.348	+0.058	.004	.003	3	6
UCEC	DOCK2_S1784 →	+0.794	+0.100	.004	.004	2	7
LSCC	MAP4K1 →	+0.385	+0.062	<.001	<.001	3	6
GBM	PLCG2 →	+0.476	+0.074	<.001	<.001	3	6
LSCC	PLCL2_S1113 →	+0.546	+0.063	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902463 vs STK4_S414 — PDAC

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