Protein localization to cell leading edge

Across TCGA patient cohorts, RNA activity of the Protein localization to cell leading edge pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCL2, LRG1, and CSF3R, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to cell leading edge activity versus CXCL2 in GBM (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CXCL2 →	+1.210	+0.357	<.001	.001	3	4
OV	LRG1 →	+1.122	+0.338	.003	.009	3	4
PDAC	CSF3R →	+0.755	+0.371	<.001	.001	3	4
PDAC	MYO1F →	+0.340	+0.332	<.001	<.001	3	4
GBM	SLA →	+0.632	+0.225	.001	.005	3	4
BRCA	PLIN2 →	-1.013	-0.430	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902463 vs CXCL2 — GBM

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