Protein localization to cell leading edge

Across TCGA cell cohorts, RNA activity of the Protein localization to cell leading edge pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZHX3, AMDHD1, and TTC5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZHX3 grouped by Protein localization to cell leading edge-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZHX3 →	-0.738	-1.569	.006	<.001	3	4
LIVER	AMDHD1 →	+1.716	+1.053	.001	.006	3	3
OVARY	TTC5 →	+1.037	+1.367	.001	.008	3	3
BREAST	MTHFD1 →	+0.467	+0.633	.008	.002	3	3
BREAST	FBL →	+0.627	+0.816	.001	.001	2	4
BLOOD_Lymphoma	ERH →	+0.519	+1.532	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZHX3 by Protein localization to cell leading edge activity — PANCREAS

Explore this box plot interactively →