Protein localization to cell leading edge

Across TCGA cell cohorts, RNA activity of the Protein localization to cell leading edge pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTCF, GRB2, and RABL2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTCF grouped by Protein localization to cell leading edge-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CTCF →	-0.300	-1.606	.001	<.001	3	5
BLOOD_Leukemia	GRB2 →	+0.246	+0.252	.002	<.001	3	5
PANCREAS	RABL2B →	+0.305	+0.109	<.001	.005	3	4
BONE	ACOXL →	+0.292	+0.207	.001	<.001	3	4
BREAST	TCL6 →	-0.162	-0.117	.006	.001	3	4
BLOOD_Leukemia	SLC2A10 →	-0.209	-0.229	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTCF by Protein localization to cell leading edge activity — BLOOD_Myeloma

Explore this box plot interactively →