Protein localization to cell leading edge

Across TCGA cell cohorts, RNA activity of the Protein localization to cell leading edge pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIM1, MBD3L1, and CDK8, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIM1 grouped by Protein localization to cell leading edge-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PIM1 →	-0.085	-1.623	.003	<.001	3	3
LUNG_SCLC	MBD3L1 →	-0.522	-0.227	.008	.009	3	3
PANCREAS	CDK8 →	+0.173	+0.347	.001	.008	3	3
URINARY_TRACT	DMPK →	-0.173	-1.606	.002	<.001	3	2
URINARY_TRACT	CLDN16 →	+0.143	+1.606	<.001	<.001	3	2
URINARY_TRACT	SLC27A2 →	-0.343	-1.606	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIM1 by Protein localization to cell leading edge activity — URINARY_TRACT

Explore this box plot interactively →