Positive regulation of mesenchymal stem cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of mesenchymal stem cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FKBP10, ITGA5, and RCN3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mesenchymal stem cell proliferation activity versus FKBP10 in LSCC (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FKBP10 →	+0.490	+0.079	<.001	<.001	3	10
COAD	ITGA5 →	+0.581	+0.067	<.001	<.001	3	10
COAD	RCN3 →	+0.751	+0.092	<.001	<.001	3	10
COAD	PPM1F →	+0.315	+0.089	<.001	<.001	3	10
UCEC	TAGLN_S166 →	+0.885	+0.087	<.001	<.001	3	9
CCRCC	C1QB →	+0.693	+0.074	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902462 vs FKBP10 — LSCC

Explore this scatter interactively →