Positive regulation of mesenchymal stem cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of mesenchymal stem cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBP1, PMEPA1, and IGFBP1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mesenchymal stem cell proliferation activity versus RBP1 in CNS (Pearson r = 0.95).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RBP1 →	+7.909	+1.655	<.001	.003	3	2
CNS	PMEPA1 →	+2.653	+1.517	.002	<.001	3	2
CNS	IGFBP1 →	+0.426	+1.517	.001	<.001	3	2
CNS	SYTL5 →	+4.090	+1.517	<.001	<.001	3	2
CNS	C6orf141 →	+4.819	+1.517	.007	<.001	3	2
CNS	MCAT →	+0.720	+1.517	.009	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902462 vs RBP1 — CNS

Explore this scatter interactively →