Positive regulation of stem cell population maintenance

Across TCGA patient cohorts, RNA activity of the Positive regulation of stem cell population maintenance pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPM, TROAP, and SYNC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of stem cell population maintenance activity versus CPM in OV (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CPM →	-1.257	-0.392	.001	.003	3	5
BRCA	TROAP →	+1.143	+0.400	<.001	.001	3	5
BRCA	SYNC →	-0.745	-0.457	.002	.004	3	5
BRCA	GPX3 →	-0.947	-0.398	.001	.002	2	6
UCEC	CD59 →	-0.564	-0.257	.004	.005	3	5
LSCC	PHLDA3 →	-0.626	-0.229	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902459 vs CPM — OV

Explore this scatter interactively →