Positive regulation of stem cell population maintenance

Across TCGA cell cohorts, RNA activity of the Positive regulation of stem cell population maintenance pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCDIN3D, OGFRL1, and TMEM11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BCDIN3D grouped by Positive regulation of stem cell population maintenance-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BCDIN3D →	+0.653	+0.274	<.001	.002	3	5
CNS	OGFRL1 →	-1.126	-0.224	.007	.009	2	5
CNS	TMEM11 →	+0.378	+0.180	.001	.003	3	4
LUNG_NSCLC_LUSC	GNAI2 →	-1.318	-0.389	.007	.001	3	4
LUNG_NSCLC_LUSC	MPP1 →	-3.719	-0.457	.002	<.001	3	4
LUNG_NSCLC_LUSC	HABP4 →	-1.630	-0.342	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BCDIN3D by Positive regulation of stem cell population maintenance activity — BLOOD_Leukemia

Explore this box plot interactively →