Positive regulation of stem cell population maintenance

Across TCGA cell cohorts, RNA activity of the Positive regulation of stem cell population maintenance pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB11FIP5, RCC2, and SFPQ, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of stem cell population maintenance activity versus RAB11FIP5 in BLOOD_Lymphoma (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RAB11FIP5 →	-1.744	-1.005	.001	<.001	3	8
BLOOD_Lymphoma	RCC2 →	+0.992	+1.514	<.001	<.001	3	7
BREAST	SFPQ →	+0.545	+1.540	.005	.002	3	7
BLOOD_Leukemia	SF3A2 →	+0.465	+0.726	.001	.003	3	6
BREAST	NASP →	+1.075	+1.584	<.001	<.001	3	6
LUNG_SCLC	HMGN2 →	+0.998	+0.319	.001	<.001	1	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902459 vs RAB11FIP5 — BLOOD_Lymphoma

Explore this scatter interactively →