Regulation of attachment of mitotic spindle microtubules to kinetochore

Across TCGA patient cohorts, RNA activity of the Regulation of attachment of mitotic spindle microtubules to kinetochore pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUF2, GINS1, and E2F1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of attachment of mitotic spindle microtubules to kinetochore activity versus NUF2 in BRCA (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NUF2 →	+1.286	+0.510	<.001	<.001	3	7
LSCC	GINS1 →	+0.947	+0.704	<.001	<.001	3	6
UCEC	E2F1 →	+1.250	+0.722	<.001	<.001	3	6
BRCA	RAD51AP1 →	+0.945	+0.418	<.001	<.001	3	6
BRCA	TTK →	+1.272	+0.510	<.001	<.001	3	6
UCEC	CDC20 →	+1.496	+0.677	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902423 vs NUF2 — BRCA

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