Regulation of attachment of mitotic spindle microtubules to kinetochore

Across TCGA cell cohorts, RNA activity of the Regulation of attachment of mitotic spindle microtubules to kinetochore pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB12, CCDC117, and UIMC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of attachment of mitotic spindle microtubules to kinetochore activity versus RAB12 in LARGE_INTESTINE (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RAB12 →	-0.571	-0.075	.001	.003	3	5
PANCREAS	CCDC117 →	-0.503	-0.112	.003	.004	3	4
KIDNEY	UIMC1 →	-0.718	-0.274	<.001	.002	3	4
BLOOD_Lymphoma	MRPL53 →	-0.407	-0.176	.008	.002	3	4
SKIN	THG1L →	-0.622	-0.102	<.001	<.001	3	4
URINARY_TRACT	ACBD5 →	-0.985	-0.206	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902423 vs RAB12 — LARGE_INTESTINE

Explore this scatter interactively →