Protein localization to cell junction

Across TCGA patient cohorts, RNA activity of the Protein localization to cell junction pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CGGBP1, SASH3, and SNRPA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to cell junction activity versus CGGBP1 in HNSC (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CGGBP1 →	-0.286	-0.037	.001	.005	3	5
LSCC	SASH3 →	-0.305	-0.032	.009	.001	3	5
LSCC	SNRPA →	-0.138	-0.029	.001	.001	3	5
BRCA	UBE2J1 →	-0.524	-0.027	<.001	<.001	3	5
BRCA	AGAP2 →	-0.339	-0.021	.007	.005	3	5
BRCA	LCK →	-0.479	-0.024	.006	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902414 vs CGGBP1 — HNSC

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