Protein localization to cell junction

Across TCGA cell cohorts, RNA activity of the Protein localization to cell junction pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF251, EEF1D, and STK38, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF251 grouped by Protein localization to cell junction-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZNF251 →	-0.667	-0.527	.007	.008	3	4
BLOOD_Myeloma	EEF1D →	-0.906	-0.358	.005	.002	2	5
BLOOD_Leukemia	STK38 →	+1.491	+1.241	.003	.009	3	4
BLOOD_Leukemia	ARHGAP9 →	-1.439	-1.137	.004	<.001	3	4
LUNG_SCLC	ZMYM4 →	-0.916	-0.239	<.001	.001	3	3
LUNG_SCLC	ZCCHC7 →	-0.530	-0.179	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF251 by Protein localization to cell junction activity — OVARY

Explore this box plot interactively →