Mitotic cytokinetic process

Across TCGA patient cohorts, RNA activity of the Mitotic cytokinetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CIP2A, RRM2, and SMC2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic cytokinetic process activity versus CIP2A in LUAD (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CIP2A →	+0.603	+0.072	<.001	<.001	3	7
LUAD	RRM2 →	+0.761	+0.084	<.001	<.001	3	7
LUAD	SMC2 →	+0.606	+0.082	<.001	<.001	3	7
LUAD	TACC3_S71 →	+1.047	+0.070	<.001	<.001	3	7
BRCA	TERF2IP_S154 →	+0.813	+0.047	<.001	<.001	3	7
LUAD	TK1 →	+0.746	+0.087	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902410 vs CIP2A — LUAD

Explore this scatter interactively →