Mitotic cytokinetic process

Across TCGA patient cohorts, RNA activity of the Mitotic cytokinetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMN, NUF2, and NEK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic cytokinetic process activity versus AMN in CCRCC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	AMN →	+1.143	+0.179	.006	.001	3	5
OV	NUF2 →	+0.821	+0.234	<.001	.001	3	4
OV	NEK2 →	+0.719	+0.193	.004	.005	3	3
OV	HJURP →	+0.971	+0.182	<.001	.007	3	3
OV	DLGAP5 →	+0.656	+0.150	.004	.001	3	3
OV	RACGAP1 →	+0.767	+0.208	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902410 vs AMN — CCRCC

Explore this scatter interactively →