Protein localization to bicellular tight junction

Across TCGA patient cohorts, RNA activity of the Protein localization to bicellular tight junction pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TJP1, PHLDB1_S324, and ARHGEF17, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to bicellular tight junction activity versus TJP1 in CCRCC (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TJP1 →	+0.377	+0.083	<.001	<.001	3	8
BRCA	PHLDB1_S324 →	+1.026	+0.096	<.001	<.001	3	6
BRCA	ARHGEF17 →	+0.330	+0.086	<.001	<.001	3	6
COAD	NRDC →	-0.177	-0.048	.001	.003	3	6
PDAC	TJP1_S179 →	+1.030	+0.034	.001	.003	2	6
BRCA	CAVIN1_S175 →	+1.201	+0.082	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902396 vs TJP1 — CCRCC

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