Protein localization to bicellular tight junction

Across TCGA patient cohorts, RNA activity of the Protein localization to bicellular tight junction pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTA2, TAGLN, and PDLIM3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to bicellular tight junction activity versus ACTA2 in OV (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ACTA2 →	+1.657	+0.860	.001	<.001	3	7
OV	TAGLN →	+1.459	+1.042	.001	<.001	3	7
OV	PDLIM3 →	+1.475	+0.861	.001	<.001	2	8
PDAC	HSD17B6 →	+0.800	+0.672	<.001	<.001	3	7
LSCC	CALD1 →	+0.746	+0.708	<.001	<.001	3	7
BRCA	FBN1 →	+1.240	+0.767	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902396 vs ACTA2 — OV

Explore this scatter interactively →