Protein localization to bicellular tight junction

Across TCGA cell cohorts, RNA activity of the Protein localization to bicellular tight junction pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F11R, TJP1, and PATJ, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to bicellular tight junction activity versus F11R in LIVER (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	F11R →	+2.651	+0.214	.002	.008	3	10
OESOPHAGUS	TJP1 →	+1.361	+0.242	<.001	.001	3	7
PANCREAS	PATJ →	+1.205	+0.370	<.001	.006	3	7
PANCREAS	TSPAN2 →	+2.292	+0.374	.002	.007	3	7
PANCREAS	CAPN1 →	+1.212	+0.442	.001	.005	2	8
PANCREAS	SH2D3A →	+3.124	+0.451	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902396 vs F11R — LIVER

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