Negative regulation of RNA catabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of RNA catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM28, TNS2_S820, and FGD5_S699, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of RNA catabolic process activity versus TRIM28 in HNSC (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRIM28 →	+0.205	+0.068	.001	.005	3	5
LUAD	TNS2_S820 →	-0.353	-0.032	.002	.001	3	4
OV	FGD5_S699 →	+1.322	+0.049	.006	<.001	3	4
HNSC	PARP1 →	+0.418	+0.076	<.001	<.001	3	4
GBM	CTSL →	+0.257	+0.025	.003	.006	3	4
LSCC	ARHGAP32_S682 →	-0.332	-0.025	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902369 vs TRIM28 — HNSC

Explore this scatter interactively →