Negative regulation of RNA catabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of RNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2S1, WAPL, and FANCD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of RNA catabolic process activity versus EIF2S1 in OVARY (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	EIF2S1 →	+1.054	+0.291	<.001	<.001	3	6
LARGE_INTESTINE	WAPL →	+0.502	+0.190	<.001	<.001	3	6
BREAST	FANCD2 →	+0.761	+0.136	<.001	.001	3	6
OVARY	NPM1 →	+1.091	+0.357	.001	<.001	3	5
OVARY	RRP9 →	+1.070	+0.295	.001	<.001	3	5
OVARY	SNUPN →	+0.729	+0.327	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902369 vs EIF2S1 — OVARY

Explore this scatter interactively →