Positive regulation of apoptotic process involved in morphogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of apoptotic process involved in morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APBB1IP, ARHGAP45, and PLCB2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of apoptotic process involved in morphogenesis activity versus APBB1IP in UCEC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	APBB1IP →	+0.541	+0.086	.002	.004	3	7
UCEC	ARHGAP45 →	+0.562	+0.105	<.001	<.001	3	7
LSCC	PLCB2 →	+0.434	+0.087	<.001	<.001	3	7
UCEC	RCSD1 →	+0.625	+0.112	<.001	<.001	3	6
UCEC	SPI1 →	+0.601	+0.083	.001	.001	3	6
GBM	SYK →	+0.477	+0.088	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902339 vs APBB1IP — UCEC

Explore this scatter interactively →