Positive regulation of apoptotic process involved in morphogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of apoptotic process involved in morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BAX, TNFRSF1B, and NOTCH1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BAX grouped by Positive regulation of apoptotic process involved in morphogenesis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BAX →	-0.393	-1.500	<.001	<.001	3	12
BREAST	TNFRSF1B →	-0.207	-1.198	<.001	<.001	3	8
BLOOD_Leukemia	NOTCH1 →	-0.263	-1.263	.004	<.001	3	6
CNS	VDR →	-0.273	-0.949	.001	.008	3	6
KIDNEY	CLDN14 →	-0.220	-1.427	.009	<.001	3	4
LUNG_NSCLC_LUSC	PRSS12 →	-0.231	-1.238	.008	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BAX by Positive regulation of apoptotic process involved in morphogenesis activity — CNS

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