Positive regulation of apoptotic process involved in morphogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of apoptotic process involved in morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELK4, MFSD10, and ADCY1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ELK4 grouped by Positive regulation of apoptotic process involved in morphogenesis-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ELK4 →	+0.561	+1.466	.003	<.001	3	3
URINARY_TRACT	MFSD10 →	+1.372	+1.713	.007	<.001	3	3
URINARY_TRACT	ADCY1 →	+1.631	+1.220	.003	.006	3	3
SOFT_TISSUE	TMEM263 →	-1.034	-1.141	<.001	.001	3	3
OESOPHAGUS	RPL26L1 →	-0.600	-0.566	<.001	.008	3	3
BLOOD_Leukemia	CAPNS2 →	-0.286	-1.358	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ELK4 by Positive regulation of apoptotic process involved in morphogenesis activity — BONE

Explore this box plot interactively →