Positive regulation of apoptotic process involved in morphogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of apoptotic process involved in morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PML, UBA7, and BCCIP, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of apoptotic process involved in morphogenesis activity versus PML in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PML →	+1.350	+0.253	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	UBA7 →	+2.323	+0.215	<.001	<.001	3	10
URINARY_TRACT	BCCIP →	-0.665	-0.210	.005	.001	3	10
UPPER_AERODIGESTIVE_TRACT	PARP10 →	+1.529	+0.143	.003	.009	3	10
OVARY	SNX33 →	+0.762	+0.106	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	TRIM22 →	+3.719	+0.221	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902339 vs PML — UPPER_AERODIGESTIVE_TRACT

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