Negative regulation of sodium ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of sodium ion transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HECW2_S1042, IFT88_S124, and RPL4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of sodium ion transmembrane transport activity versus HECW2_S1042 in CCRCC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HECW2_S1042 →	+0.849	+0.110	<.001	.001	3	5
UCEC	IFT88_S124 →	-0.851	-0.072	.001	.001	3	5
UCEC	RPL4 →	-0.238	-0.050	.003	.001	3	4
LSCC	EPB41L1_S564 →	+1.100	+0.066	<.001	<.001	3	4
LSCC	EPB41L1_S650 →	+0.870	+0.050	<.001	.001	3	4
OV	RUFY1_S165 →	-0.778	-0.076	.004	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902306 vs HECW2_S1042 — CCRCC

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