Negative regulation of sodium ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of sodium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMK2D, SPART, and ATP5PB, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of sodium ion transmembrane transport activity versus CAMK2D in BLOOD_Leukemia (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CAMK2D →	+2.400	+2.089	.003	<.001	3	9
BLOOD_Lymphoma	SPART →	-4.111	-1.146	<.001	.008	3	4
BLOOD_Lymphoma	ATP5PB →	+1.047	+1.251	.003	.006	3	3
BLOOD_Lymphoma	CDKN2C →	+2.347	+1.118	.005	.008	3	3
BLOOD_Lymphoma	CABLES2 →	+0.816	+1.307	.002	<.001	3	3
BLOOD_Lymphoma	AUTS2 →	+2.488	+1.073	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902306 vs CAMK2D — BLOOD_Leukemia

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