Regulation of sodium ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Regulation of sodium ion transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EMILIN1, DCHS1, and BCAT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sodium ion transmembrane transport activity versus EMILIN1 in LUAD (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EMILIN1 →	-0.433	-0.045	<.001	<.001	3	6
PDAC	DCHS1 →	-0.373	-0.042	<.001	<.001	3	6
OV	BCAT1 →	-1.101	-0.026	.008	.005	3	5
UCEC	EFEMP2 →	-0.543	-0.045	<.001	<.001	3	5
COAD	FKBP7 →	-0.488	-0.025	<.001	<.001	3	5
COAD	L3HYPDH →	-0.360	-0.032	.001	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902305 vs EMILIN1 — LUAD

Explore this scatter interactively →