Regulation of sodium ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Regulation of sodium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HJURP, KIF23, and PIF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sodium ion transmembrane transport activity versus HJURP in BRCA (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HJURP →	-1.085	-0.293	<.001	<.001	3	6
BRCA	KIF23 →	-0.865	-0.429	<.001	<.001	3	6
LUAD	PIF1 →	-0.713	-0.678	<.001	<.001	3	6
GBM	GJB1 →	+1.579	+0.740	<.001	<.001	3	6
BRCA	CCNB2 →	-1.148	-0.381	<.001	<.001	3	6
BRCA	CDC6 →	-0.671	-0.366	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902305 vs HJURP — BRCA

Explore this scatter interactively →