Regulation of sodium ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Regulation of sodium ion transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSP90AA1, PCBP1, and AHSA1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sodium ion transmembrane transport activity versus HSP90AA1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.71).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	HSP90AA1 →	-1.288	-0.213	<.001	<.001	3	12
STOMACH	PCBP1 →	-1.032	-0.261	.001	.005	3	10
UPPER_AERODIGESTIVE_TRACT	AHSA1 →	-2.114	-0.306	<.001	<.001	3	10
PANCREAS	CHP1 →	+1.386	+0.283	<.001	<.001	3	10
BONE	BOLA2B →	-2.267	-0.618	<.001	.001	3	10
BONE	BOLA2 →	-2.267	-0.618	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902305 vs HSP90AA1 — UPPER_AERODIGESTIVE_TRACT

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