Regulation of chromatin organization

Across TCGA patient cohorts, RNA activity of the Regulation of chromatin organization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM28, PBRM1, and SMC1A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chromatin organization activity versus TRIM28 in HNSC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRIM28 →	+0.330	+0.092	<.001	<.001	3	7
GBM	PBRM1 →	+0.340	+0.057	<.001	<.001	3	7
GBM	SMC1A →	+0.320	+0.040	.003	.003	3	6
GBM	SMC3 →	+0.324	+0.045	.001	.001	3	6
COAD	SF3B3 →	+0.159	+0.035	.002	<.001	3	6
HNSC	RPL26 →	-0.478	-0.108	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902275 vs TRIM28 — HNSC

Explore this scatter interactively →