Regulation of polyamine transmembrane transport

Across TCGA patient cohorts, RNA activity of the Regulation of polyamine transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HARS2, ANKFY1, and SAMHD1_S33, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of polyamine transmembrane transport activity versus HARS2 in CCRCC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HARS2 →	-0.401	-0.074	<.001	<.001	3	6
LSCC	ANKFY1 →	-0.264	-0.042	<.001	<.001	3	5
LSCC	SAMHD1_S33 →	-0.367	-0.029	<.001	<.001	3	5
HNSC	THG1L →	-0.177	-0.051	.007	.005	2	6
PDAC	NUCB1_S369 →	-0.697	-0.028	<.001	.001	3	5
CCRCC	GUCY1B1 →	+0.366	+0.058	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902267 vs HARS2 — CCRCC

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