Regulation of delayed rectifier potassium channel activity

Across TCGA patient cohorts, RNA activity of the Regulation of delayed rectifier potassium channel activity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1orf226_S198, DLG3, and ARFGEF3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of delayed rectifier potassium channel activity activity versus C1orf226_S198 in LSCC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C1orf226_S198 →	+0.655	+0.027	.005	.008	3	6
GBM	DLG3 →	+0.385	+0.066	<.001	<.001	3	5
BRCA	ARFGEF3 →	+0.508	+0.040	<.001	.001	3	5
BRCA	ARHGEF12_S1541 →	+0.766	+0.073	.001	.001	3	5
BRCA	S100A8 →	-1.160	-0.044	<.001	<.001	3	5
UCEC	DDX47 →	-0.257	-0.046	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902259 vs C1orf226_S198 — LSCC

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