Regulation of delayed rectifier potassium channel activity

Across TCGA patient cohorts, RNA activity of the Regulation of delayed rectifier potassium channel activity pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANK3, FAAH, and ZSWIM5, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of delayed rectifier potassium channel activity activity versus ANK3 in CCRCC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ANK3 →	+1.299	+0.686	<.001	<.001	3	10
GBM	FAAH →	+0.825	+0.556	<.001	<.001	3	6
CCRCC	ZSWIM5 →	+0.778	+0.512	.001	.004	3	5
CCRCC	ANXA2P2 →	-0.629	-0.521	<.001	.003	3	5
UCEC	HMGB1P41 →	+0.943	+0.858	.004	<.001	3	5
PDAC	TAGLN →	-0.737	-0.589	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902259 vs ANK3 — CCRCC

Explore this scatter interactively →