Regulation of delayed rectifier potassium channel activity

Across TCGA cell cohorts, RNA activity of the Regulation of delayed rectifier potassium channel activity pathway is significantly associated with the protein abundance of multiple proteins, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGB1, PFAS, and LRRC7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of delayed rectifier potassium channel activity activity versus ITGB1 in BONE (Pearson r = -0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ITGB1 →	-2.088	-0.300	.003	.002	3	5
BLOOD_Lymphoma	PFAS →	+0.713	+0.247	.006	.002	3	4
BLOOD_Myeloma	LRRC7 →	-0.598	-0.201	<.001	.008	3	4
BLOOD_Lymphoma	HTATSF1 →	+0.534	+0.197	.005	.003	3	4
BONE	HSPA5 →	-0.684	-0.339	.003	<.001	3	4
BONE	PPIB →	-1.148	-0.337	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902259 vs ITGB1 — BONE

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