Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator

Across TCGA patient cohorts, RNA activity of the Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KMT2B_S821, TFAP4_S139, and CKAP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator activity versus KMT2B_S821 in GBM (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KMT2B_S821 →	+0.347	+0.072	.002	<.001	3	5
LSCC	TFAP4_S139 →	+0.475	+0.054	.004	.007	3	5
BRCA	CKAP4 →	-0.490	-0.056	<.001	<.001	3	5
UCEC	ATP11C_S445 →	+0.643	+0.099	<.001	<.001	3	5
PDAC	ZFYVE19_S144 →	-0.355	-0.068	<.001	<.001	3	5
LUAD	ARCN1 →	-0.159	-0.071	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902255 vs KMT2B_S821 — GBM

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