Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator

Across TCGA cell cohorts, RNA activity of the Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCO1, C1QBP, and CARM1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator activity versus SCO1 in BLOOD_Myeloma (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SCO1 →	+0.939	+0.222	.004	.009	3	8
PANCREAS	C1QBP →	+1.295	+0.290	<.001	.001	3	7
PANCREAS	CARM1 →	+1.118	+0.380	.002	<.001	3	7
PANCREAS	TBPL1 →	+1.012	+0.344	.002	.001	3	7
LARGE_INTESTINE	SOX12 →	+1.083	+0.247	<.001	<.001	3	7
BLOOD_Myeloma	EIF5A →	+1.227	+0.217	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902255 vs SCO1 — BLOOD_Myeloma

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