Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator

Across TCGA patient cohorts, RNA activity of the Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMG1, NFAT5, and USP45, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator activity versus SMG1 in UVM (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	SMG1 →	+1.156	+0.053	<.001	<.001	3	29
CHOL	NFAT5 →	+1.691	+0.087	.001	.002	3	28
UVM	USP45 →	+0.959	+0.062	<.001	<.001	3	28
UVM	USP15 →	+1.192	+0.063	<.001	<.001	3	28
UVM	FAM160B1 →	+1.174	+0.058	<.001	<.001	3	28
UVM	MYSM1 →	+1.535	+0.060	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902254 vs SMG1 — UVM

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