Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator

Across TCGA patient cohorts, RNA activity of the Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBBP5, RPS13, and SERPINA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator activity versus RBBP5 in LSCC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RBBP5 →	+0.221	+0.026	<.001	.004	3	5
BRCA	RPS13 →	-0.275	-0.059	<.001	<.001	3	4
COAD	SERPINA3 →	+0.523	+0.034	.007	.009	3	4
COAD	TBRG4 →	-0.338	-0.037	<.001	<.001	3	4
BRCA	TKFC →	+0.346	+0.038	<.001	<.001	3	4
OV	TOP1_S394 →	-0.582	-0.050	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902254 vs RBBP5 — LSCC

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