Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator

Across TCGA patient cohorts, RNA activity of the Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC7, ARID3A, and DDX27, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator activity versus LRRC7 in GBM (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LRRC7 →	-0.798	-0.146	<.001	<.001	3	4
COAD	ARID3A →	-0.625	-0.400	.008	.005	3	3
COAD	DDX27 →	-0.739	-0.504	.002	.008	3	3
COAD	DDC →	-0.903	-0.462	<.001	.006	3	3
COAD	ENPP7P7 →	-0.555	-0.593	<.001	<.001	3	3
CCRCC	IFITM3 →	+0.399	+0.173	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902254 vs LRRC7 — GBM

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