Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator

Across TCGA cell cohorts, RNA activity of the Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGB3BP, GCLC, and BORCS5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGB3BP grouped by Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ITGB3BP →	-0.363	-0.255	.001	.001	2	5
LARGE_INTESTINE	GCLC →	+0.750	+0.454	.004	.005	3	3
LARGE_INTESTINE	BORCS5 →	+0.437	+0.440	.008	.007	3	3
OVARY	BICDL1 →	+1.364	+0.830	.001	.003	3	3
OVARY	GANAB →	-0.503	-1.024	.001	.007	3	3
OESOPHAGUS	TEAD2 →	-1.598	-0.234	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGB3BP by Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator activity — OESOPHAGUS

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