Regulation of intrinsic apoptotic signaling pathway by p53 class mediator

Across TCGA cell cohorts, RNA activity of the Regulation of intrinsic apoptotic signaling pathway by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TENT5B, OSBPL9, and MTCL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TENT5B grouped by Regulation of intrinsic apoptotic signaling pathway by p53 class mediator-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TENT5B →	-1.171	-0.152	<.001	.001	3	5
BLOOD_Leukemia	OSBPL9 →	-1.002	-0.174	.006	.009	2	6
BLOOD_Leukemia	MTCL1 →	-2.795	-0.196	.007	<.001	3	5
URINARY_TRACT	ITGA1 →	-1.305	-0.213	.006	<.001	3	4
OESOPHAGUS	IL10RB →	+0.786	+0.137	.001	.009	3	4
BREAST	SLC9A3R1 →	+2.797	+0.244	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TENT5B by Regulation of intrinsic apoptotic signaling pathway by p53 class mediator activity — SKIN

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