Regulation of intrinsic apoptotic signaling pathway by p53 class mediator

Across TCGA cell cohorts, RNA activity of the Regulation of intrinsic apoptotic signaling pathway by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC26, UBE3C, and WDR36, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intrinsic apoptotic signaling pathway by p53 class mediator activity versus TTC26 in BREAST (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TTC26 →	+0.696	+0.180	.005	.001	3	6
CNS	UBE3C →	+0.617	+0.175	.006	.002	3	6
OVARY	WDR36 →	+0.881	+0.257	<.001	.002	3	5
BREAST	GBE1 →	+1.351	+0.182	.009	.002	3	5
BREAST	CEP97 →	+0.788	+0.223	<.001	.001	3	5
CNS	CUL1 →	+0.651	+0.165	.005	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902253 vs TTC26 — BREAST

Explore this scatter interactively →