Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RN7SKP16, NKTR, and TSSK4, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway activity versus RN7SKP16 in GBM (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RN7SKP16 →	+0.736	+0.040	<.001	<.001	3	28
UVM	NKTR →	+1.289	+0.062	<.001	<.001	3	27
THYM	TSSK4 →	+0.742	+0.047	<.001	<.001	3	27
UVM	MYSM1 →	+1.562	+0.060	<.001	<.001	3	27
UVM	GOLGB1 →	+1.136	+0.063	<.001	<.001	3	27
ACC	POFUT2 →	+0.976	+0.042	.001	.004	2	28

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902236 vs RN7SKP16 — GBM

Explore this scatter interactively →